Sepsis 3.0 guidelines from 2016. Knowledge of the SOFA score has increased in importance since this was published. SIRS still exists as a concept but has been removed from the definition.
Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection
Sepsis = Suspected infection + qSOFA>2 + organ dysfunction
Septic shock = Sepsis + Vasopressor requirement to MAP >65 + lactate >2 despite adequate fluid resuscitation
qSOFA (Quick SOFA) Criteria
Respiratory rate >22/min
Systolic blood pressure <100 mm Hg